Usar "exacerbation" en una oración

1. But nothing came to him, except for an exacerbation of pain in his head

2. Fronts of potential solutions confront storms of potential exacerbation, with positive feedback loops triggering unpredictable tipping points with variable cascade resolutions furthering instability, volatility, and thus, storm production

3. year smoking history presenting with her third COPD exacerbation of the year

4. � The exacerbation of the issue also confuses what is actually happening and creates a kind of cognitive dissonance