Use "vicissitude" in a sentence

1. So great a vicissitude in his life could not at once be

2. But the added power of the boat did not equal the added power of the whale, for he seemed to have treble-banked his every fin; swimming with a velocity which plainly showed, that if now, under these circumstances, pushed on, the chase would prove an indefinitely prolonged, if not a hopeless one; nor could any crew endure for so long a period, such an unintermitted, intense straining at the oar; a thing barely tolerable only in some one brief vicissitude

3. Assuring myself, that, under every vicissitude, the determined spirit and united councils of the nation will be safeguards to its honor and its essential interests, I repair to the post assigned me with no other discouragement than what springs from my own inadequacy to its high duties